IJOCP | April 2014 | Volume 1 | Issue 1 | Page 18
Conference: North Zone Indian Orthopaedic Association Conference, 2014 – Amritsar, India [Click for Full details]  

Authors: Udai Singh Cheema[1],A.S Sidhu[1] , Nishat Setia[1] ,  Kanish Kinra[1] , Sartaj Singh Gill[1]
Authors Affiliations: [1] Maharishi Markandeshwar Institute of Medical Sciences and Research , M.M University , Mullana-Ambala , Haryana

Address of Correspondence
Dr Udai Singh Cheema

Flat no: 13 , H-Block Maharishi Markandeshwar University Mullana ,Ambala Haryana – 133207.
Email: drudaicheema@yahoo.com


Abstract                                                                                                                 

Introduction – Tranexamic acid,inhibitor of fibrinolysis blocks lysine-binding site of plasminogen to fibrin,decreasing blood loss in operative patients. Prospective, randomized , double-blind study was done on 50 patients undergoing total hip arthroplasty to determine effect of tranexamic acid on intra- and post operative blood loss and blood transfusion requirements.

Material & Methods: We investigated effects of tranexamic acid in fifty patients , twenty five randomized patients were given bolus intravenous injection of tranexamic acid(15mg/kg)and twenty five given intravenous placebo(normal saline),15minutes before skin incision. Intraoperative and postoperative blood loss and number of blood transfusions required recorded and values were compared between two groups. The patients were screened for deep vein thrombosis with bilateral venous color doppler ultrasonography on tenth postoperative day.Baseline haemoglobin and hematocrit values were obtained three weeks before each arthroplasty.

Results: Patients receiving tranexamic acid had mean intraoperative blood loss 400+100ml versus 610+150ml(p value<0.05)in patients receiving placebo, postoperative blood loss of 380+150ml versus 550+ 220ml (p value<0.05) in patients on placebo after twenty four hours. Total need for 9 blood transfusions versus 30. 8 out of 25 patients in tranexamic acid group required blood transfusion whereas 20 out of 25 patients in placebo group required transfusion. In placebo group mean fall in haemoglobin was 2.8g/dl (range2.4-3.4) and in the tranexamic acid group1.5g/dl(1.1-2.0)(p<0.05).No patient in either group had evidence of deep vein thrombosis on bilateral color doppler ultrasonography of lower limbs.

Conclusion: Study showed that a single preoperative intravenous bolus dose of Tranexamic acid 15mg/kg reduces perioperative, postoperative and total blood loss,it also reduces transfusion requirements in total hip arthroplasty without increasing risk of thromembolic complications.


How to Cite this Abstract
Cheema S Udai , Sidhu A.S ,  Setia Nishat,   Kinra Kanish,  Gill S Sartaj . Role of Tranexamic Acid in Reducing Intra and Postoperative Blood Loss in Total Hip Rep;acement Surgery. April 2014;1(1):18.