Can we predict diaphyseal fracture healing outcome early? Evaluation of serum alkaline phosphatase as a biomarker of healing process progression
|IJOCP | Volume – 2015| Issue – 2015| Article ID – 2015:72
Conference: Indian Orthopaedic Association Annual Conference IOACON-2013, India [Click for Full details]
Authors: Singh A, Srivastava R N
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Clinicians are unable to identify delayed and nonunions early. Changes in serum ALP levels were noted at definitive intervals in 95 adult patients with simple diaphyseal fractures of both bones leg. Patients were followed till either bone union was completed or maximum up to the end of 09 month. All 95 patients were allocated into 02 groups; Group A: clinicoradiological union achieved before or by the end of 06 months; and Group B: clinico-radiological union not completed by 06 months. The Group B was further subdivided into B1: clinico-radiological healing not completed by 06 months but completed by 09 months; and B2: clinico-radiological healing not achieved even by the end of 09 months (Non-union).
At the time of admission, mean serum ALP levels remained within normal limits in all patients. Mean serum ALP levels followed the same pattern in group A and B1, reaching a maximum level at post trauma 3rd week. But the mean levels of serum ALP at every selected interval was significantly higher in group A. In Group A, serum ALP levels returned to normal values by complete union achieved, where as in group B1 values remained elevated even by the end of 06 months. In Group B2, mean serum ALP level remained within normal limits throughout the followup. The serum ALP levels estimation could be additional tool in predicting fractures at risk of delayed/nonunion of diaphyseal fractures.
|How to Cite this Abstract|
|Singh A, Srivastava R N . Can we predict diaphyseal fracture healing outcome early? Evaluation of serum alkaline phosphatase as a biomarker of healing process progression. International Journal of Conference Proceedings 2015;(2015):72|