IJOCP | April 2014 | Volume 1 | Issue 1 | Page 10
Conference: North Zone Indian Orthopaedic Association Conference, 2014 – Amritsar, India [Click for Full details]  

Authors: Rakesh Sharma
Authors Affiliations:Deptt. Of Orthopaedics, GMC, Amritsar
Address of Correspondence:
Dr. Rakesh Sharma  :  Associate Prof.,

Deptt. Of Orthopaedics, GMC, Amritsa
Email- drrksharma50@yahoo.com



For degenerative osteoarthritis of the knees, a variety of non-surgical management options have been tried from time to time. Medical management, chondroprotective agents, disease modifying drugs, viscosupplimentation etc. to name a few.Arthroscopic  knee lavage with saline also has shown good short term results, with the effect of cleaning the debries from the joint.
Growth  Factors  Rich Plasma  (GFRP)or Platelet Rich Plasma (PRP)  is an emerging  treatment therapy called  ” Orthobiologics”.  Alfa granules  in platelets contain numerous growth factors which enhance tissue recovery dramatically by catalyzing the body’s natural healing response. PRP also attracts Mesenchymal Stem Cells , which differentiate into  variety of cell types during tissue repair processes & induce the production of new collagen by the fibroblasts, osteoblasts and  chondrocytes  as per the need of the parent tissue.

Material & Methods:   Knee lavage is done under local anaesthesia using single antero-lateral portal.Four liters of saline is used to lavage the knee and at the end of procedure 80 mg. methyl prednisolone is injected. For GFRP injection, 100 cc of patient’s blood is double centrifuged in the refrigerated blood component separator centrifuge in the blood bank giving  about 15 cc of  buffy layer having GFRP.


Since Feb. 2010, more than 500 knees of different grades of osteoarthritis have been injected with GFRP and the results  compared with  other different  treatment  options. Results of few different  combination therapies are presented in this study.

  1. Knee Lavage  Vs Autologus GFRP Injection  (100+100 cases)
  2. Knee Lavage + Autologus GFRP Injection in 1 knee  Vs  GFRP Injection only in other knee (100+100 cases)
  3. Visco-supplimentationVsAutologus GFRP Injection. (10+10cases)

Results were analysedup  to 1 year as per  VAS scale

It has been observed that  Knee Lavage and GFRP  Injection  have almost similar efficacy at 1 year, though  knee lavage starts showing its effects early. GFRP  therapy  has shown better results compared to viscosupplimentation  at 1 year. Combination of knee lavage with GFRP injection showed much better results than GFRP injection aloneand the results are inversely related to the grade of the osteoarthritis.

Conclusion:  It’s concluded that Knee Lavage followed by GFRP injection gives the best long term results  andthis pilot project initiated, hopefully will go a long way in future to change the course of the management for early osteoarthritis knees at a minimal cost.

How to Cite this Abstract
Sharma Rakesh. Autologus  Growth Factors Rich Plasma (GFRP) Injection  Following  Arthroscopic  Knee  Lavage– A Reliable Management Option for Early Osteoartritis Knees. I J Orthopaedic Conference Proceedings. April 2014;1(1):10.